Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
SILVA, Cristiana Silveira; RAMOS, Rodrigo de Oliveira; PIRES, Mario Cezar and SITTART, José Alexandre S.. Epidermodysplasia verruciformis: combined treatment with acitretin and interferon alpha-2a. An. Bras. Dermatol. [online]. 2006, vol.81, n.6, pp. 595-597. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962006000600013.
We report the result of a treatment with acitretin and alpha-2a interferon in a 16-year-old boy with epidermodysplasia verruciformis. Diagnosis was based on clinical features, histopathological examination and positivity for in situ HPV. The affection was extensive and resistant to other treatment modalities, with a high risk of development of neoplasias. Treatment with oral acitretin associated with subcutaneous recombinant interferon alpha-2a three times per week induced improvement, which was sustained for 16 months of follow-up.
Keywords : Acitretin; Epidermodysplasia verruciformis; Interferon alpha-2a.