Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
JORGE, Aline Donati et al. Frequency analysis of thrombophilia in patients with atrophie blanche. An. Bras. Dermatol. [online]. 2007, vol.82, n.1, pp. 25-33. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962007000100003.
INTRODUCTION: Atrophie blanche, or livedoid vasculopathy, is a rare clinicopathological entity of unknown etiology. A "thrombo-occlusive process" theory has recently been accepted. OBJECTIVES: To search the presence of several thrombophilic abnormalities in patients with livedoid vasculopathy. METHODS: Fourteen patients were evaluated and tested for factor V Leiden, prothrombin 20210G/A variant, antithrombin, C and S proteins, anticardiolipin and lupus anticoagulant antibodies, homocysteine and methylenetetrahydrofolate reductase mutation. RESULTS: Nine patients met all criteria to be included in the analysis and four of them had a thrombophilic state: antithrombin deficiency (one case), protein S deficiency (one case), methylenetetrahydrofolate reductase mutation with hyperhomocysteinemia (one case) and presence of anticardiolipin antibodies (one case). CONCLUSIONS: Although this tendency cannot be statistically proven, thrombophilic abnormalities seem to be more frequent in patients with atrophie blanche, indicating that screening for thrombophilia of all patients with livedoid vasculopathy might be recommended.
Keywords : Antiphospholipid syndrome; Antithrombin III; Atrophy; Blood vessels; Leg ulcer; Skin diseases, vascular; Thrombophilia; Thrombophilia [etiology]; Thrombosis; Vasculitis.