SciELO - Scientific Electronic Library Online

vol.82 issue1Frequency analysis of thrombophilia in patients with atrophie blancheEpidemiological profile of women with bacterial vaginosis treated at a clinic for sexually transmitted diseases in the city of Sao Paulo, SP author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596On-line version ISSN 1806-4841


VELA, Rodrigo Alessandro R. et al. Detection and genotyping of human papillomavirus in solitary keratoacanthoma lesions of immunocompetent patients. An. Bras. Dermatol. [online]. 2007, vol.82, n.1, pp.35-40. ISSN 0365-0596.

BACKGROUND - Keratoacanthoma is a benign cutaneous neoplasm that preferentially affects fair skin individuals of older age groups and involves sun-exposed areas. Apart from ultraviolet radiation exposure, its etiology is related to several carcinogens, including human papillomavirus (HPV) infection. OBJECTIVES: To assess the prevalence of HPV DNA and its genotypes in solitary keratoacanthoma lesions of immunocompetent patients. Methods: Keratoacanthoma lesions of patients with no evidence of immunological involvement, excised from 1996 to 2000, at a university hospital, were assessed. Histological aspects, deparafinization and DNA extraction of these lesions were evaluated. The specimens positive for HPV DNA were submitted to gene sequencing to determine the genotype. RESULTS: Fifty-eight patients were studied, mean age of 64.5±13.8 years. Both sexes were similarly affected, and the most common sites were upper limbs (50%) and face (27.6%). HPV DNA was detected in 48 (82.7%) keratoacanthoma fragments, and the genotypes 6, 11 and 16 were the most prevalent. CONCLUSIONS: The high prevalence of HPV DNA in solitary keratoacanthoma lesions may suggest viral participation in its oncogenesis.

Keywords : Keratoacanthoma; Papillomavirus; Polymerase chain reaction; Sequence analysis with oligonucleotid series.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License