SciELO - Scientific Electronic Library Online

 
vol.82 issue2Contact dermatitis in elderly patientsFrequency of onychomycoses caused by yeasts in Maringa, Parana, Brazil author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Anais Brasileiros de Dermatologia

On-line version ISSN 1806-4841

Abstract

TENIUS, Fernando Pundek; BIONDO-SIMOES, Maria de Lourdes Pessole  and  IOSHII, Sérgio Ossamu. Effects of chronic use of dexamethasone on cutaneous wound healing in rats. An. Bras. Dermatol. [online]. 2007, vol.82, n.2, pp. 141-149. ISSN 1806-4841.  http://dx.doi.org/10.1590/S0365-05962007000200005.

BACKGROUND: Glucocorticoids are believed to hinder healing process, causing decreased cell proliferation, neovascularization and matrix production. OBJECTIVE: To investigate the effects of the chronic use of corticosteroids on skin wound healing. METHODS: After daily injections of dexamethasone (0.1 mg/Kg) for 30 days, an excision was made in the dorsum of rats. Wound healing was evaluated at postoperative days 3, 7 and 14. Scar resistance, collagen density and inflammatory reaction were assessed by histometry. RESULTS: The scars of the dexamethasone-treated group were less resistant to traction in all days (p=0.008) and presented lower collagen density. Collagen III density was affected at all times (p<0.0001) and collagen I density was lower only on day 14 (p<0.0001). The inflammatory cell infiltration was less intense in the dexamethasone-treated group in the first two evaluations (p=0.001 and p=0.016), but there was no significant difference on day 14, (p=0.367). CONCLUSIONS: We observed decreased scar resistance and lower total collagen density in all periods studied. In the beginning of the process, low collagen III density was observed and later collagen type I density was also decreased. Reduced number of inflammatory cells was found in the first two evaluations.

Keywords : Collagen; Dexamethasone; Wound healing.

        · abstract in Portuguese     · text in Portuguese     · pdf in Portuguese