Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
LIMA, Hermênio Cavalcante. Facts and myths about immunomodulators. An. Bras. Dermatol. [online]. 2007, vol.82, n.3, pp.207-221. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962007000300002.
The objective of this article is to discuss some facts of modern immunomodulators that might be useful for clinical dermatology. Moreover, it aims to dispel myths that might have a negative impact on the use of such drugs by clinicians. The primary focus is on immunomodulators that stimulate and may enhance the normal response of immunocompetent cells. Therefore, several aspects associated to immune system regulation, and regulatory pathways of immune cells are also mentioned. Furthermore, aberrant regulation is discussed in the context of immunomodulator use and the impact this has on the immune system. This review also examines the class of immunosuppressive drugs and their wellestablished function. Several drugs were not mentioned since the article focuses on well accepted facts or myths that new scientific evidences have changed. With that in mind, it is likely that there is a considerable amount of similarity in concepts, given that they describe immunomodulating drugs. In this context, the intention to provide important insight into how the immune system can be modulated by theses drugs surpasses this problem.
Keywords : Allergy and immunology; Dermatology; Drug utilization; Physiological effects of drugs.