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Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596On-line version ISSN 1806-4841


MACEDO, Danielle Mazziero et al. Necrobiotic xanthogranuloma without paraproteinemia. An. Bras. Dermatol. [online]. 2008, vol.83, n.3, pp.243-246. ISSN 0365-0596.

Necrobiotic xanthogranuloma is a chronic granulomatous and xantomathous disease, characterized by indurated, nontender, yellowish and erythematous nodules and plaques especially located on the periorbital region. It is commonly associated with paraproteinemia and an increased risk for hematological and lymphoproliferative malignancies. Its pathogenesis remains unclear. Alkylating agents, such as chlorambucil and melphalan may be used to treat the disease with variable success. We report a case of this rare disease in a patient with a solitary tumor and without paraproteinemia.

Keywords : Granuloma; Paraproteinemias; Skin diseases, metabolic; Xanthomatosis.

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