Abstract

FERNANDES, Nurimar C. et al. Erythroderma: a clinico-laboratorial and histopathological study of 170 cases. An. Bras. Dermatol. [online]. 2008, vol.83, n.6, pp. 526-532. ISSN 1806-4841.  http://dx.doi.org/10.1590/S0365-05962008000600005.

BACKGROUND - Exfoliative dermatitis (erythroderma) is a rare, severe syndrome, frequently of unknown etiology. The hospitalization is required for the initial evaluation and to establish the treatment. OBJECTIVE - to determine the clinical, laboratorial and histologic profile of erythrodermic inpatients at HUCFF-UFRJ. METHODS - in the period 1990-2007, 170 patients were submitted to complete blood cell count, erythrocyte sedimentation rate, blood urea, glucose and creatinine, liver function tests, proteinogram, circulating Sézary cells count, chest X Rays and skin biopsy of three areas. RESULTS - from 92 male and 78 female aging 30 to 80 years, a preexisting dermatosis was identified in 99 cases (58,23%), reaction to internal drugs in 37 cases (21,77%), T cell cutaneous lymphomas in 18 cases (10,58%); in 16 cases (9,47%), a causative factor could not be disclosed. Chills, pruritus, lymphadenopathy, lower limbs edema were the most freqüent signs/symptoms. Elevated erythrocyte sedimentation rate, eosinophilia, leukocytosis, peripheral blood lymphocytosis and anemia were the most common laboratory findings. Among the idiopathic cases, two histological patterns were noticed: psoriasiform and inespecific dermatitis. CONCLUSION - the main cause of erythroderma was psoriasis; three simultaneous skin biopsies can enhance the accuracy of the histopathologic diagnosis.

Keywords : Dermatitis; exfoliative; Dermatitis; exfoliative [diagnosis]; Dermatitis; exfoliative [etiology]; Psoriasis.