Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
RSTOM, Sílvia Arroyo et al. Remission of multicentric reticulohistiocytosis with combined terapy witb infliximab. An. Bras. Dermatol. [online]. 2008, vol.83, n.6, pp.539-543. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962008000600007.
Multicentric reticulohistiocytosis is an extremely rare systemic disorder of unknown etiology. It is characterized by a severe symmetric polyarthritis which can progresses to a mutilant arthritis and papulonodular skin and mucosal lesions. The diagnostic of multicentric reticulo histiocytosis is histopathologic. Approximately one-third of the adults patients have association with malignancies. There is no uniform treatment regimen for multicentric reticulohistiocytosis. We present a case of a 46-year woman with a classical clinical picture of multicentric reticulohistiocytosis. The patient received treatment with biological immunemodulators with marked results.
Keywords : Histiocytosis; Immunologic factors; Reticulum.