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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
ANTELO, Daniela Pereira; FILGUEIRA, Absalom Lima and CUNHA, José Marcos Telles da. Reduction of cytotoxic T-CD8+ lymphocytes observed during PUVA therapy in a patient with vitiligo. An. Bras. Dermatol. [online]. 2008, vol.83, n.6, pp.572-574. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962008000600013.
The role of cytotoxic T cells (CD8+) has been emphasized in the pathogenesis of vitiligo. This cell population, identified by a skin homing molecule (cutaneous lymphocyte associated antigen Â- CLA), has been described in patients with other dermatoses and can be reduced with phototherapy. The authors present the case of a patient with generalized vitiligo and clinical recovery after PUVA parallel to a 25% reduction in CD8+-CLA+ T cells in the peripheral blood.
Keywords : Immunophenotyping; PUVA therapy; Vitiligo.