Abstract

ANTELO, Daniela Pereira; FILGUEIRA, Absalom Lima  and  CUNHA, José Marcos Telles da. Reduction of cytotoxic T-CD8⁺ lymphocytes observed during PUVA therapy in a patient with vitiligo. An. Bras. Dermatol. [online]. 2008, vol.83, n.6, pp. 572-574. ISSN 1806-4841.  http://dx.doi.org/10.1590/S0365-05962008000600013.

The role of cytotoxic T cells (CD8⁺) has been emphasized in the pathogenesis of vitiligo. This cell population, identified by a skin homing molecule (cutaneous lymphocyte associated antigen Â- CLA), has been described in patients with other dermatoses and can be reduced with phototherapy. The authors present the case of a patient with generalized vitiligo and clinical recovery after PUVA parallel to a 25% reduction in CD8⁺-CLA⁺ T cells in the peripheral blood.

Keywords : Immunophenotyping; PUVA therapy; Vitiligo.