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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
BRANDT, Hebert Roberto Clivati et al. Medium and large vessel vasculitis. An. Bras. Dermatol. [online]. 2009, vol.84, n.1, pp. 55-67. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962009000100008.
Vasculitis comprises a broad group of syndromes characterized by inflammation and necrosis on the walls of blood vessels, resulting in narrowing or occlusion of the lumen. The distribution of involved blood vessel varies considerably and serves as the basis for one classification of vasculitic syndromes: large vessels (Takayasu arteritis, giant cell arteritis); medium and small muscular arteries (polyarteritis nodosa, Churg-Strauss syndrome, Wegener's granulomatosis, vasculitis in rheumatic diseases); and small vessels ("hypersensitivity" vasculitis, Henoch-Schonlein purpura, microscopic polyangiitis, cryoglobulinemia). This article reviews medium and large vessel vasculitis and current treatment options; it also presents a comprehensive approach to diagnosing and treating patients with suspected cutaneous vasculitis.
Keywords : Antibodies, Antineutrophil Cytoplasmic; Takayasu's Arteritis; Rheumatic Diseases; Wegener Granulomatosis; Polyarteritis Nodosa; Purpura; Churg-Strauss Syndrome; Vasculitis; Vasculitis, Allergic Cutaneous.