SciELO - Scientific Electronic Library Online

 
vol.84 issue2The use of azythromycin and N-methyl glucamine for the treatment of cutaneous Leishmaniasis caused by Leishmania (Leishmania) amazonensis in C57BL6 mice author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Anais Brasileiros de Dermatologia

On-line version ISSN 1806-4841

Abstract

CUNHA, Paulo R.  and  BARRAVIERA, Silvia Regina C. S.. Autoimmune bullous dermatoses. An. Bras. Dermatol. [online]. 2009, vol.84, n.2, pp. 111-124. ISSN 1806-4841.  http://dx.doi.org/10.1590/S0365-05962009000200003.

Autoimmune bullous dermatoses are diseases in which blisters and vesicles are the primary and fundamental types of skin lesion. Their classification is based on the location of the blister: intraepidermal and subepidermal. Patients produce autoantibodies against self-specific structures of the skin detectable by immunofluorescence techniques, immunoblotting and ELISA. Recent advances in molecular and cellular biology have brought to knowledge these self-antigens, against which patients are sensitized, and which are found in epidermis or in the dermo-epidermal junction. These are low incidence, but high morbidity diseases that may be fatal. The aim of this article is to review and describe the progress of four autoimmune vesiculobullous disorders: endemic pemphigus foliaceous (wild fire), pemphigus vulgaris, bullous pemphigoid and dermatitis herpetiformis.

Keywords : Allergy and immunology; Bullous pemphigoid; Dermatitis herpetiformis; Pemphigus; Skin diseases vesiculobullous.

        · abstract in Portuguese     · text in English | Portuguese     · pdf in Portuguese