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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
CUNHA, Paulo R. and BARRAVIERA, Silvia Regina C. S.. Autoimmune bullous dermatoses. An. Bras. Dermatol. [online]. 2009, vol.84, n.2, pp. 111-124. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962009000200003.
Autoimmune bullous dermatoses are diseases in which blisters and vesicles are the primary and fundamental types of skin lesion. Their classification is based on the location of the blister: intraepidermal and subepidermal. Patients produce autoantibodies against self-specific structures of the skin detectable by immunofluorescence techniques, immunoblotting and ELISA. Recent advances in molecular and cellular biology have brought to knowledge these self-antigens, against which patients are sensitized, and which are found in epidermis or in the dermo-epidermal junction. These are low incidence, but high morbidity diseases that may be fatal. The aim of this article is to review and describe the progress of four autoimmune vesiculobullous disorders: endemic pemphigus foliaceous (wild fire), pemphigus vulgaris, bullous pemphigoid and dermatitis herpetiformis.
Keywords : Allergy and immunology; Bullous pemphigoid; Dermatitis herpetiformis; Pemphigus; Skin diseases vesiculobullous.