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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
FERNANDES, Marcelo D'Ambrosio et al. Inflammatory epidermolysis bullosa acquisita: case report. An. Bras. Dermatol. [online]. 2009, vol.84, n.2, pp.181-184. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962009000200012.
We report a case of an inflammatory variant of epidermolysis bullosa acquisita in a 53-year-old male, with itching blistering eruption on the trunk, armpits and limbs for six months. The skin biopsy specimen showed subepidermal blister with neutrophils. Direct immunofluorescence revealed linear depositions of IgG, IgA, IgM and C3 at the basement membrane; indirect immunofluorescence and salt Split Skin were negative. Antinuclear antibodies were also negative. Improvement of the blisters followed treatment with systemic corticotherapy and some lesions healed with milia. This is a rare presentation of epidermolysis bullosa acquisita, with inflammatory lesions at first.
Keywords : Basement membrane; Blister; Epidermolysis bullosa acquisita.