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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
FERREIRA, Leonardo Mello et al. Langerhans cell histiocytosis: Letterer-Siwe disease - the importance of dermatological diagnosis in two cases. An. Bras. Dermatol. [online]. 2009, vol.84, n.4, pp.405-409. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962009000400013.
Langerhans cell histiocytosis is defined as a clonal proliferation of Langerhans phenotypic-like cells. Letterer-Siwe disease is the most common and serious of these entities, affecting mainly infants up to two years of age. We present two cases of this rare disease, diagnosed after dermatological examination, highligthing its typical aspects.
Keywords : Antigen-presenting cells; Etoposide; Immunohistochemistry; Microscopy; electron; Vinblastine.