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Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596On-line version ISSN 1806-4841


SOUZA, Camila Alves de; SANTOS, Allan da Costa; SANTOS, Lennon da Costa  and  CARNEIRO, Artur Leonel. Hereditary tylosis syndrome and esophagus cancer. An. Bras. Dermatol. [online]. 2009, vol.84, n.5, pp.527-529. ISSN 0365-0596.

Tylosis palmoplantaris is an autosomal dominant disorder characterized by hyperkeratosis of palms and soles. Lesions start during childhood and are more evident in areas of pressure. Familial tylosis palmoplantaris comprises two forms: epidermolytic and non-epidermolytic. Patients with the epidermolytic variant have up to 40% higher chance of developing squamous cell carcinoma of the esophagus. The association of tylosis palmoplantaris with esophageal cancer is called Howel-Evans syndrome.

Keywords : Carcinoma, squamous cell; Esophageal neoplasms; Hyperkeratosis, epidermolytic; Keratoderma, palmoplantar, diffuse.

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