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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
TORRES, Tiago; VELHO, Glória Cunha and SELORES, Manuela. Disseminated superficial porokeratosis in a patient with cholangiocarcinoma: a paraneoplastic manifestation?. An. Bras. Dermatol. [online]. 2010, vol.85, n.2, pp.229-231. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962010000200016.
Porokeratosis refers to a group of hereditary or acquired disorders of epidermal keratinization and is characterized histologically by the presence of a cornoid lamella. The clinical variant referred to as disseminated superficial porokeratosis has been described in the literature in association with immunosuppressive conditions that include organ transplant, infections and immunosuppressive treatments. The association of disseminated superficial porokeratosis with solid organ malignancies has seldom been described, only 5 such cases having been published. The present report refers to a patient with lesions of disseminated superficial porokeratosis of sudden onset shortly before diagnosis of a cholangiocarcinoma.
Keywords : Cholangiocarcinoma; Genes, P53; Porokeratosis.