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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
MOSQUEIRA, Carolina Balbi et al. Intravenous immunoglobulin for treatment of severe acquired bullous epidermolysis refractory to conventional immunosuppressive therapy. An. Bras. Dermatol. [online]. 2010, vol.85, n.4, pp.521-524. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962010000400014.
Acquired bullous epidermolysis is a chronic and rare bullous subepidermal disease. It usually begins in adulthood and its etiology is unknown although it is associated with antibodies against type VII collagen. There are spontaneous and trauma induced formation of blisters that may cause serious complications. Treatment is disappointing and difficult. Apart from conventional therapy with systemic corticosteroid, new therapeutic modalities such as intravenous immunoglobulin are currently being used. This report highlights the extremely difficult clinical management of this rare disease and the important improvement provided by intravenous immunoglobulin.
Keywords : Acquired bullous epidermolysis; Immunosuppressive agents; Immunoglobulins, intravenous.