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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
FERNANDES, Nurimar Conceição and PINA, Juliana Carnevale. Leukoderma punctata following topical PUVAsol treatment. An. Bras. Dermatol. [online]. 2010, vol.85, n.4, pp.571-572. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962010000400026.
Two adolescent females and a girl, all with clinically diagnosed vitiligo, were treated with 0.2% 8-methoxypsoralen cream followed by exposure to solar ultraviolet light. One year later, they developed hypopigmented and achromic spots on the areas affected by the vitiligo. Biopsy of skin tissue taken from one of these cases showed a marked reduction in melanin. Clinical and histological findings point to a diagnosis of leukoderma punctata.
Keywords : Hypopigmentation; Psoralens; Vitiligo.