SciELO - Scientific Electronic Library Online

vol.85 issue5Human adipose-derived stem cells: current challenges and clinical perspectivesOral lichen planus (OLP): clinical and complementary diagnosis author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596


PERES, Nalu Teixera de Aguiar; MARANHAO, Fernanda Cristina Albuquerque; ROSSI, Antonio  and  MARTINEZ-ROSSI, Nilce Maria. Dermatophytes: host-pathogen interaction and antifungal resistance. An. Bras. Dermatol. [online]. 2010, vol.85, n.5, pp.657-667. ISSN 0365-0596.

Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphogenesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trigger the immune response against the infectious agent. The comprehension of the molecular aspects of these responses may help to establish new therapeutical strategies. In this review, different aspects of the biology of dermatophytes are addressed, with emphasis on the dermatophyte-host interaction and the mechanisms of antifungal resistance.

Keywords : Antifungal agents; Dermatomycoses; Drug resistance, fungal; Host-pathogen interactions.

        · abstract in Portuguese     · text in English | Portuguese     · English ( pdf epdf ) | Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License