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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
BESSA, Giancarlo Rezende et al. Hailey-Hailey disease treatment with Botulinum toxin type A. An. Bras. Dermatol. [online]. 2010, vol.85, n.5, pp.717-722. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962010000500021.
Two sisters with recurrent lesions, one on axillae and other on the groin, and with limited response to classical treatments were treated with injections botulinum toxin type A. We observed marked improvement in the patient treated in the groin and complete remission in the patient treated in the axillae. It was possible to spare the use of systemic antibiotics and topical corticosteroids. The high cost is a restrictive factor to routine use and large studies are necessary to access efficacy and cost benefit profile.
Keywords : Botulinum toxin type A; Combined modality therapy; Pemphigus, benign familial.