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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
FRANCA, Emmanuel Rodrigues de et al. Cutaneous effects after prolongaded use of hydroxyurea in Polycythemia Vera. An. Bras. Dermatol. [online]. 2011, vol.86, n.4, pp.751-754. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962011000400019.
Hydroxyurea is an hydroxylated urea derivative used in many myeloproliferative disorders. Many, but unusual cutaneous disorders are related after its prolonged use. Their pathogenesis is not clear, but it is suggested that there is direct toxicity of the drug on the skin. We described a white, 75-year old man with diagnosis of Polycythemia Vera that in 11 years of treatment developed many cutaneous lesions: skin hyperpigmentation, atrophic lesions on forearms, longitudinal melanonychia of 20 nails, right forearm ulcer, cutaneous xerosis, ichthyosis and auricular spinocellular carcinoma. At this moment, the literature reports describe little diversity of lesions in affected patients
Keywords : Hydroxyurea; Polycythemia vera; Skin manifestations.