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Anais Brasileiros de Dermatologia
On-line version ISSN 1806-4841
LIMA, Emerson de Andrade and LIMA, Mariana de Andrade. Reviewing concepts in the immunopathogenesis of psoriasis. An. Bras. Dermatol. [online]. 2011, vol.86, n.6, pp.1151-1158. ISSN 1806-4841. http://dx.doi.org/10.1590/S0365-05962011000600014.
Insights into the pathogenesis of psoriasis led to the development of therapeutic tools aimed at blocking its immunological trigger. In parallel, cytokines such as the tumor necrosis factor (TNF) have been recognized as playing a crucial role in the pathogenesis of psoriasis and its associated comorbidities. Genetic and immunological studies have contributed effectively towards establishing the currently held concepts regarding this complex disease.
Keywords : Antigens, CD4; Interferon-stimulated gene factor 3; Interleukin-4; Psoriasis; Th1 cells; Tumor necrosis factor-alpha.