Anais Brasileiros de Dermatologia
Print version ISSN 0365-0596
BARBOSA, Wanessa Simão et al. Lúpus eritematoso sistêmico bolhoso: diagnóstico diferencial com dermatite herpetiformeBullous systemic lupus erythematosus: differential diagnosis with dermatitis herpetiformis. An. Bras. Dermatol. [online]. 2011, vol.86, n.4, suppl.1, pp. 92-95. ISSN 0365-0596. http://dx.doi.org/10.1590/S0365-05962011000700024.
Bullous systemic lupus erythematosus is a rare subset of systemic lupus erythematosus that is even rarer in pediatric patients. We report a case of a 12-year-old girl who presented with a vesiculobullous eruption on her face, neck, trunk and genital and oral mucosa, as well as anemia, sterile pyuria, ANA (1:1280, speckled pattern) and positive anti-Sm and anti-RNP. Pathological examination suggested dermatitis herpetiformis, and direct immunofluorescence revealed IgG, IgA and fibrin in the epithelial basement membrane zone. We present a typical case of bullous systemic lupus erythematosus and emphasize the importance of clinical and histopathological differential diagnosis with dermatitis herpetiformis
Keywords : Autoimmunity; Dermatitis herpetiformis; Lupus erythematosus, Systemic; Skin Diseases; Type VII collagen; Vesiculobullous.