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Anais Brasileiros de Dermatologia
Print version ISSN 0365-0596
On-line version ISSN 1806-4841
JAIME, Thais Jerez et al. Disseminated hypertrophic lichen planus: relevant response to acitretin. An. Bras. Dermatol. [online]. 2011, vol.86, n.4, suppl.1, pp.96-99. ISSN 0365-0596. http://dx.doi.org/10.1590/S0365-05962011000700025.
Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squamous cell carcinoma requires an effective treatment. The first-line treatment is corticosteroids which can be applied either topically or systemically. Other therapeutic modalities proposed are: NB-UVB phototherapy or PUVA, immunosuppressive drugs and systemic retinoids, notably acitretin. We report a case with exuberant clinical presentation of hyperthrofic lichen planus with excellent response to acitretin after nine months of treatment
Keywords : Acitretin; Immunosuppressive drugs; Lichen planus; Prednisone.