Obesity and dyslipidemia in patients with psoriasis treated
               at a dermatologic clinic in Manaus

Santos, Mônica; Fonseca, Hannah Monteiro; Jalkh, Alex Panizza; Gomes, Gabriela Piraice; Cavalcante, Andrea de Souza

doi:10.1590/abd1806-4841.20132090

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Investigation • An. bras. dermatol. 88 (6) • Nov-Dec 2013 • https://doi.org/10.1590/abd1806-4841.20132090 copy

Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus^* * Work carried out at the Dermatology Clinic of the Tropical Medicine Foundation (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado - FMTAM) - Manaus (AM), Brazil.

Obesidade e dislipidemia em pacientes com psoríase atendidos num ambulatório de dermatologia de Manaus

Authorship SCIMAGO INSTITUTIONS RANKINGS

BACKGROUND:

Psoriasis is a chronic inflammatory disease of multifactorial etiology, with participation of genetic, autoimmune and environmental factors. Recent studies have demonstrated the role of inflammatory cells and mediators in the pathogenesis of psoriasis, which is now defined as a systemic and autoimmune inflammatory disease that may be associated with other diseases of inflammatory nature.

OBJECTIVES:

To evaluate the occurrence of obesity and dyslipidemia in patients with psoriasis treated at a dermatology clinic in Manaus.

METHODS:

We performed a prospective descriptive study to assess the prevalence of obesity and dyslipidemia in patients with psoriasis. Besides the recommended dermatological care, a physical examination was performed to measure weight, height and waist circumference.

RESULTS:

We included 72 patients, 44 (61.1%) female and 28 (38.9%) male, with a mean age of 51.0 years ± 15.9 years. As for body mass index (BMI), 16 (22.2%) were overweight and 20 (27.8%) were obese. In the analysis of waist circumference in relation to gender, we found that 79.5% of women surveyed had central obesity, a percentage statistically higher than that observed among men (42.9%) at the 5% level of significance (p = 0.001). Regarding the diagnosis of dyslipidemia, 29 (65.9%) females and 22 (78.6%) males showed alterations in lipid profile.

CONCLUSIONS:

The occurrence of dyslipidemia and obesity in patients with psoriasis can affect life quality and expectancy, increasing the risk of systemic and metabolic diseases, which makes periodic investigation of these comorbidities in patients with psoriasis mandatory.

Dyslipidemias; Obesity; Psoriasis

Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 18. and., 20090-003 Rio de Janeiro RJ, Tel./Fax: +55 21 2253-6747 - Rio de Janeiro - RJ - Brazil
E-mail: revista@sbd.org.br

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[1] MAILING ADDRESS: Mônica Santos, Av. Pedro Teixeira, 25 - Dom Pedro, 69040-000 - Manaus - AM, Brazil. E-mail: m.n.souza.santos@gmail.com

Variable n=72	f1	%
Gender
Female	44	61.1
Male	28	38.9
Age (years)
< 25	3	4.2
25 \|--- 35	8	11.1
35 \|--- 45	15	20.8
45 \|--- 55	13	18.1
55 \|--- 65	19	26.4
≥ 65	14	19.4
Mean ±SD	51.0 ± 15.9
Time since diagnosis (years)
< 01	13
01 \|--- 05	19
05 \|--- 10	15
10 \|--- 20	17
≥ 20	8
Median	5.0
Q1-Q3	01-10

Variables (n=72)	n	Median	Q1 - Q3	*p^ * Chi Square Test of Pearson. Value of p in bold indicates statistical association at the 5% significance level**
Hypertensive				0.099
Yes	25	8.0	1-12
No	47	3.0	1-10
Diabetes				0.041
Yes	14	8.5	6-11
No	58	3.0	1-10

	Gender
Physical	Female	Male
Examination	(n = 44)	(n = 28)
	f_l	%	f_l	%	Total	*p^ * Chi Square Test of Pearson. Value of p in bold indicates statistical association at the 5% significance level**
Obesity (IMC≥30)						0.904
Yes	12	16.7	8	11.1	20
Overweight (IMC 25 - 29.9)						0.803
Yes	10	13.8	6	8.3	16
Abdominal
Circumference						0.001
Obese	35	79.5	12	42.9	47
Normal	9	20.5	16	57.1	25
Dyslipidemia						0.249
Yes	29	65.9	22	78.6	51
No	15	34.1	6	21.4	21

Variables (n+72)	f1	%
Cholesterol >240
Yes	8	11.1
No	64	88.9
HDL <50 in Women (n+44)
Yes	28	63.6
No	16	36.4
HDL < 40 in Men (n=28)
Yes	16	57.1
No	12	42.9
Triglycerides>150
Yes	35	49.3
No	36	50.7
LDL>160
Yes	6	8.3
No	66	91.7

Variables (n=72)	n	Median	Q₁ - Q₃	*P^ * Nonparametric Mann-Whitney Test. Value of p in bold italic indicates statistical association at the 5% significance level**
Obesity (BMI >30				0,714
Yes	20	5.0	1-11
No	52	5.0	1-10
Abdominal Obesity				0.022
Yes	47	7.0	1-10
No	25	1.0	0-10
Dyslipidemia				0.132
Yes	51	8.0	1-12
No	21	3.0	1-5

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Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus* * Work carried out at the Dermatology Clinic of the Tropical Medicine Foundation (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado - FMTAM) - Manaus (AM), Brazil.

Obesidade e dislipidemia em pacientes com psoríase atendidos num ambulatório de dermatologia de Manaus

BACKGROUND:

OBJECTIVES:

METHODS:

RESULTS:

CONCLUSIONS:

Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus^* * Work carried out at the Dermatology Clinic of the Tropical Medicine Foundation (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado - FMTAM) - Manaus (AM), Brazil.