COMT
|
22q11.1-q11.2 |
C C |
50 / 66 |
Turkish |
Acrofacial |
val108/158met |
Exon 3 |
P=0.047 |
NA |
Tursen et al, |
2002 131131 Tursen U, Kaya TI, Erdal ME, Derici E, Gunduz O, Ikizoglu G. Association between catechol-O-methyltransferase polymorphism and vitiligo. Arch Dermatol Res. 2002;294:143-6.
|
|
C C |
749 / 763 |
Chinese |
Vulgaris / localized - IIP |
rs4680 |
Exon 3 |
P<0.001 |
1.42 (1.15 - 1.75) |
Li et al, |
2009 132132 Li K, Li C, Gao L, Yang L, Li M, Liu L, et al. A functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene alter vitiligo risk in a Chinese population. Archives of dermatological research. 2009;301:681-7.
|
|
|
C C |
1392 / 2629 |
European |
Generalized |
rs4680 |
Exon 3 |
NS |
-
|
Birlea et al, |
2011 4747 Birlea SA, Jin Y, Bennett DC, Herbstman DM, Wallace MR, McCormack WT, et al. Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. J Invest Dermatol. 2011;131:371-81.
|
DDR1
|
6p21 |
B F |
188 F (596 IND)
|
Brazilian |
Vitiligo per se |
rs4618569 |
5'Near Gene |
P=0.002 |
5.27 (1.59 - 17.40) |
Silva de et al, |
20106161 Silva de Castro CC, do Nascimento LM, Walker G, Werneck RI, Nogoceke E, Mira MT. Genetic variants of the DDR1 gene are associated with vitiligo in two independent Brazilian population samples. J Invest Dermatol. 2010;130:1813-8.
|
|
|
|
|
|
rs1049623 |
Exon 15 |
P=0.05 |
1.73 (0.97 - 3.08) |
|
|
|
|
|
|
|
|
rs2267641 |
Exon 17 |
P=0.01 |
3.47 (1.22 - 9.17) |
|
|
|
|
C C |
134 / 134 |
Brazilian |
Vitiligo per se |
rs2267641 |
Exon 17 |
P=0.04 |
6.0 (1.73 - 52.33) |
Silva de et al, |
2010 6161 Silva de Castro CC, do Nascimento LM, Walker G, Werneck RI, Nogoceke E, Mira MT. Genetic variants of the DDR1 gene are associated with vitiligo in two independent Brazilian population samples. J Invest Dermatol. 2010;130:1813-8.
|
|
|
C C |
220 / 409 |
Korean |
Non-segmenta |
l rs1049623 |
Exon 15 |
NS |
- |
Kim et al, |
2010 6262 Kim HJ, Uhm YK, Yun JY, Im SH, Yim SV, Chung JH, et al. Association between polymorphisms of discoidin domain receptor tyrosine kinase 1 (DDR1) and non-segmental vitiligo in the Korean population. Eur J Dermatol. 2010;20:231-2.
|
|
|
C C |
1392 / 2629 |
European |
Generalized |
rs2267641 |
Exon 17 |
NS |
-
|
Birlea et al, |
2011 4747 Birlea SA, Jin Y, Bennett DC, Herbstman DM, Wallace MR, McCormack WT, et al. Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. J Invest Dermatol. 2011;131:371-81.
|
NLRP1
|
17p13 |
B F |
114 F (656 IND)
|
American / European |
Generalized + DAA |
rs6502867 |
Intron 15 |
P< 0.001
|
2.8 (1.37 - 3.15) |
Jin et al, |
2007 3636 Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, et al. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med. 2007;356:1216-25.
|
|
|
|
|
|
rs4790797 |
|
P<0.001a |
2.1 (1.39 - 2.91) |
|
|
|
|
|
C C |
66 / 93 |
Romanian |
Generalized |
rs6502867 |
Intron 15 |
P= 0.019
|
1.86 (1.09 - 3.21) |
Jin et al, |
2007 5959 Jin Y, Birlea SA, Fain PR, Spritz RA. Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population. J Invest Dermatol. 2007;127:2558-62.
|
|
|
|
|
|
|
rs2670660 |
|
P=0.039
|
1.54 (1.03 - 2.39) |
|
|
|
|
C C |
26 / 61 |
Arab |
Generalized |
rs1008588 |
|
P=0.027 |
N.A |
Alkhateeb et al, |
2010 6060 Alkhateeb A, Qarqaz F. Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs. Arch Dermatol Res. 2010;302:631-4.
|
|
|
|
|
|
|
rs2670660 |
|
P=0.038 |
N.A |
|
|
PTPN22
|
1p13.3-p13.1 |
C C |
165 / 304 |
European |
Generalized |
1858 C/T |
Exon 14 (R620W) |
P=0.005
|
1.82 (1.17 - 2.82) |
Canton et al, |
2005 133133 Canton I, Akhtar S, Gavalas NG, Gawkrodger DJ, Blomhoff A, Watson PF, et al. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Genes Immun. 2005;6:584-7.
|
|
|
C C |
126 / 140 |
Indian |
Generalized |
1858 C/T (R620W) |
Exon 14 |
NS |
-
|
Laddha et al, |
2008 134134 Laddha NC, Dwivedi M, Shajil EM, Prajapati H, Marfatia YS, Begum R. Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population. J Dermatol Sci. 2008;49:260-2.
|
|
|
C C |
65 / 111 |
Romanian |
Generalized |
1858 C/T (R620W) |
Exon 14 |
P=0.036
|
2.92 (1.21 - 7.03) |
LaBerge et al, |
2008 135135 Laberge GS, Birlea SA, Fain PR, Spritz RA. The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population. Pigment Cell Melanoma Res. 2008;21:206-8.
|
|
|
B F |
126 F (712 IND)
|
American / European |
Generalized + DAA |
1858 C/T (R620W) |
Exon 14 |
P=0.024
|
2.16 (1.22 - 3.82) |
LaBerge et al, |
2008 136136 LaBerge GS, Bennett DC, Fain PR, Spritz RA. PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not. J Invest Dermatol. 2008;128:1757-62.
|
|
|
C C |
55 / 85 |
Arab |
Generalized |
1858 C/T (R620W) |
Exon 14 |
NS |
-
|
Alkhateeb et al, |
2010 6060 Alkhateeb A, Qarqaz F. Genetic association of NALP1 with generalized vitiligo in Jordanian Arabs. Arch Dermatol Res. 2010;302:631-4.
|
XBP1
|
22q12.1 |
C C |
319 / 294 |
Chinese Han |
Vitiligo per se |
rs2269577 |
Promoter |
P=0.007 |
1.36 (1.09 - 1.71) |
Ren et al, |
2009 3737 Ren Y, Yang S, Xu S, Gao M, Huang W, Gao T, et al. Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo. PLoS Genet. 2009;5:e1000523.
|
|
|
|
365 / 404 |
Chinese Han |
Vitiligo per se |
rs2269577 |
Promoter |
P= 0.008 |
1.31 (1.07 - 1.59) |
|
|
|
|
|
1402 / 1288 |
Chinese Han |
Vitiligo per se |
rs2269577 |
Promoter |
P=0.003 |
1.18 (1.06 - 1.32) |
|
|
|
|
C C |
896 / 1515 |
European |
Generalized |
rs2269577 |
Promoter |
P=0.00075 |
1.17 (1.06 - 1.29) |
Birlea et al, |
2011 4747 Birlea SA, Jin Y, Bennett DC, Herbstman DM, Wallace MR, McCormack WT, et al. Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. J Invest Dermatol. 2011;131:371-81.
|
|
|
M A |
2653 / 2980 |
European / Chinese |
|
rs2269577 |
Promoter |
P= 0.0000000095 |
1.21 (1.13 - 1.19) |
|
|