SciELO - Scientific Electronic Library Online

vol.90 número6Guidelines of the Brazilian Dermatology Society for diagnosis, treatment and follow up of primary cutaneous melanoma - Part IDiagnostic methods to cutaneous leishmaniasis detection in domestic dogs and cats índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Anais Brasileiros de Dermatologia

versão impressa ISSN 0365-0596versão On-line ISSN 1806-4841


FESTUGATO, Moira. Adenosine: an endogenous mediator in the pathogenesis of psoriasis. An. Bras. Dermatol. [online]. 2015, vol.90, n.6, pp.862-867. ISSN 1806-4841.

It is known that inflammatory and immune responses protect us from the invasion of micro-organisms and eliminate "wastes" from the injured sites, but they may also be responsible for significant tissue damage. Adenosine, as a purine nucleoside, which is produced in inflamed or injured sites, fulfills its role in limiting tissue damage. Although, it may have a pleiotropic effect, which signals it with a proinflammatory state in certain situations, it can be considered a potent anti-inflammatory mediator. The effects of adenosine, which acts through its receptors on T cell, on mast cell and macrophages, on endothelial cells, on neutrophils and dendritic cells, as they indicate TNF-alpha and cytokines, show that this mediator has a central role in the pathogenesis of psoriasis. The way it acts in psoriasis will be reviewed in this study.

Palavras-chave : Adenosine; Caffeine; Cyclic AMP; Methotrexate; Psoriasis; Th17 Cells.

        · texto em Inglês     · Inglês ( pdf )