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Anais Brasileiros de Dermatologia

versão impressa ISSN 0365-0596versão On-line ISSN 1806-4841

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FESTUGATO, Moira. Adenosine: an endogenous mediator in the pathogenesis of psoriasis. An. Bras. Dermatol. [online]. 2015, vol.90, n.6, pp.862-867. ISSN 1806-4841.  http://dx.doi.org/10.1590/abd1806-4841.20153689.

It is known that inflammatory and immune responses protect us from the invasion of micro-organisms and eliminate "wastes" from the injured sites, but they may also be responsible for significant tissue damage. Adenosine, as a purine nucleoside, which is produced in inflamed or injured sites, fulfills its role in limiting tissue damage. Although, it may have a pleiotropic effect, which signals it with a proinflammatory state in certain situations, it can be considered a potent anti-inflammatory mediator. The effects of adenosine, which acts through its receptors on T cell, on mast cell and macrophages, on endothelial cells, on neutrophils and dendritic cells, as they indicate TNF-alpha and cytokines, show that this mediator has a central role in the pathogenesis of psoriasis. The way it acts in psoriasis will be reviewed in this study.

Palavras-chave : Adenosine; Caffeine; Cyclic AMP; Methotrexate; Psoriasis; Th17 Cells.

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