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Anais Brasileiros de Dermatologia

versão impressa ISSN 0365-0596versão On-line ISSN 1806-4841

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QUARESMA, Maria Victória et al. Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent. An. Bras. Dermatol. [online]. 2015, vol.90, n.3, suppl.1, pp.51-54. ISSN 1806-4841.  http://dx.doi.org/10.1590/abd1806-4841.20153408.

Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.

Palavras-chave : Dapsone; Hepatitis; Pemphigus; Prednisone.

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