Angiosarcoma in HIV-negative patients is not associated with HHV-8

Avancini, João; Sanches, José Antonio; Cherubim, Andre Pires Zanata; Pazzini, Renato; Oliveira, Cristina Mendes de; Sumita, Laura Masami; Valente, Neusa Yuriko Sakai; Pannuti, Claudio Sergio; Festa Neto, Cyro

doi:10.1590/abd1806-4841.20164730

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Sumário

Investigation • An. Bras. Dermatol. 91 (6) • Nov-Dec 2016 • https://doi.org/10.1590/abd1806-4841.20164730 copy

Angiosarcoma in HIV-negative patients is not associated with HHV-8^* * Work performed at the Universidade de São Paulo (USP) – São Paulo (SP), Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract:

BACKGROUND:

Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.

OBJECTIVE:

To investigate the relationship between the presence of HHV-8 and angiosarcoma.

METHODS:

In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.

RESULTS:

While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.

CONCLUSION:

These findings support most previous studies that found no association between HHV-8 and angiosarcoma.

Keywords:
Hemangiosarcoma; Herpesvirus 8, human; HIV

Patient	Age (years)	Gender	Ethnicity	Affected site
1	85	female	Caucasian	scalp
2	72	male	Asian	head
3	68	female	Caucasian	head
4	69	female	Caucasian	arm
5	72	male	Caucasian	head
6	67	male	Caucasian	head
7	81	male	Caucasian	head
8	79	female	Caucasian	leg
9	66	male	Caucasian	scalp
10	70	female	Caucasian	head
11	70	female	Caucasian	leg
12	59	female	Caucasian	scalp
13	80	female	Caucasian	arm
14	75	male	Black	head
15	70	male	Caucasian	head

Patient	Diagnosis	Histological review	β-globin	VR1	VR2	ORF-73	K12	HHV-8 result
1	AS	Confirmed	positive	-	-	-	-	negative
2	AS	Confirmed	positive	-	-	-	-	negative
3	AS	Confirmed	positive	-	-	-	-	negative
4	AS	Confirmed	positive	-	-	-	-	negative
5	AS	Confirmed	positive	-	-	-	-	negative
6	AS	Confirmed	positive	-	-	-	-	negative
7	AS	Confirmed	positive	-	-	-	-	negative
8	AS	Confirmed	positive	-	-	-	-	negative
9	AS	Confirmed	positive	-	-	-	-	negative
10	AS	Confirmed	positive	-	-	-	-	negative
11	AS	Confirmed	positive	-	-	-	-	negative
12	AS	Confirmed	positive	-	-	-	-	negative
13	AS	Confirmed	positive	-	-	-	-	negative
14	AS	Confirmed	negative	-	-	-	-	excluded
15	AS	Confirmed	positive	-	-	-	-	negative
16	EKS	Confirmed	positive	-	-	+	-	positive
17	EKS	Confirmed	positive	-	-	+	-	positive
18	EKS	Confirmed	positive	-	-	+	-	positive
19	EKS	Confirmed	positive	-	-	+	-	positive
20	EKS	Confirmed	positive	-	-	-	+	positive
21	EKS	Confirmed	positive	+	+	+	-	positive
22	EKS	Confirmed	positive	-	-	+	+	positive
23	EKS	Confirmed	positive	-	-	+	+	positive
24	EKS	Confirmed	positive	+	+	+	-	positive
25	EKS	Confirmed	negative	-	-	-	-	excluded
26	EKS	Confirmed	positive	-	-	+	-	positive
27	EKS	Confirmed	low	-	-	-	-	negative

Authors	Number of cases	Positivity for HHV-8 in AS % (n)
Mc Donagh et al.⁷7 McDonagh DP, Liu J, Gaffey MJ, Layfield LJ, Azumi N, Traweek ST. Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in angiosarcoma. Am J Pathol. 1996;149:1363-8., 1996	24	29 (7/24)
Tomita et al.²¹21 Tomita Y, Naka N, Aozasa K, Cesarman E, Knowles DM. Absence of Kaposi's-sarcoma-associated herpesvirus-like DNA sequences (KSHV) in angiosarcomas developing in body-cavity and other sites. Int J Cancer. 1996;66:141-2., 1996	35	none
Dictor et al.²²22 Dictor M, Rambech E, Way D, Witte M, Bendsöe N. Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) DNA in Kaposi's sarcoma lesions, AIDS Kaposi's sarcoma cell lines, endothelial Kaposi's sarcoma simulators, and the skin of immunosuppressed patients. Am J Pathol. 1996;148:2009-16., 1996	10	none
Jin et al.²³23 Jin YT, Tsai ST, Yan JJ, Hsiao JH, Lee YY, Su IJ. Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in vascular lesions. A reliable diagnostic marker for Kaposi's sarcoma. Am J Clin Pathol. 1996;105:360-3., 1996	15	none
Koizumi et al.¹⁵15 Koizumi H, Ohkawara A, Itakura O, Kikuta H. Herpesvirus-like DNA sequences in classic Kaposi's sarcoma and angiosarcoma in Japan. Br J Dermatol. 1996;135:1009-10., 1996	2	50 (1/2)
Gyulai et al.¹⁶16 Gyulai R, Kemény L, Kiss M, Adám E, Nagy F, Dobozy A. Herpesvirus-like DNA sequence in angiosarcoma in a patient without HIV infection. N Engl J Med. 1996;334:540-1., 1996	1	100 (1/1)
Gyulai et al.¹⁷17 Gyulai R, Kemény L, Kiss M, Nagy S, Adám E, Nagy F, et al. Human herpesvirus 8 DNA sequences in angiosarcoma of the face. Br J Dermatol. 1997;137:467., 1997	1	100 (1/1)
Takata et al.²⁴24 Takata M, Hatta N, Takehara K, Fujiwara H. Absence of human herpesvirus-8 DNA in angiosarcomas and other skin tumours in immunocompetent patients, and in graft-versus-host disease in the immunosuppressed recipients of bone marrow transplants. Br J Dermatol. 1997;137:156-7., 1997	10	none
Viviano et al.²⁵25 Viviano E, Romano N, Sorce M, Castelli E, Marasà L. Absence of human herpesvirus 8 DNA in benign and malignant endothelial lesions. J Clin Microbiol. 1997;35:3010., 1997	17	none
Lasota et al.²⁶26 Lasota J, Miettinen M Absence of Kaposi's sarcoma-associated virus (human herpesvirus-8) sequences in angiosarcoma. Virchows Arch. 1999;434:51-6., 1999	33	none
Palacios et al.²⁷27 Palacios I, Umbert I, Celada A. Absence of human herpesvirus-8 DNA in angiosarcoma. Br J Dermatol. 1999;140:170-1., 1999	11	none
Karpati et al.¹⁸18 Kárpáti S, Désaknai S, Désaknai M, Bíró J, Nagy K, Horváth A. Human herpesvirus type 8-positive facial angiosarcoma developing at the site of botulinum toxin injection for blepharospasm. Br J Dermatol. 2000;143:660-2., 2000	1	100 (1/1)
Remick et al.¹⁹19 Remick SC, Patnaik M, Ziran NM, Liegmann KR, Dong J, Dowlati A, et al. Human herpesvirus-8-associated disseminated angiosarcoma in an HIV-seronegative woman: report of a case and limited case-control virologic study in vascular tumors. Am J Med. 2000;108:660-4., 2000	1	100 (1/1)
Fink-Puches et al.²⁸28 Fink-Puches R, Zöchling N, Wolf P, Bäck B, Kerl H, Soyer HP. No detection of human herpesvirus 8 in different types of cutaneous angiosarcoma. Arch Dermatol. 2002;138:131-2, 2002	19	none
Gessi et al.²⁰20 Gessi M, Cattani P, Maggiano N, Scambia G, Lauriola L, Ranelletti FO, et al. Demonstration of human herpesvirus 8 in a case of primary vaginal epithelioid angiosarcoma by in situ hybridization, electron microscopy, and polymerase chain reaction. Diagn Mol Pathol. 2002;11:146-51., 2002	1	100 (1/1)
Kamiyama et al. ³⁰30 Kamiyama K, Kinjo T, Chinen K, Iwamasa T, Uezato H, Miyagi JI, et al. Human herpesvirus 8 (HHV8) sequence variations in HHV8 related tumours in Okinawa, a subtropical island in southern Japan. J Clin Pathol. 2004;57:529-35., 2004	1	none
Schmid et al. ⁶6 Schmid H, Zietz C. Human herpesvirus 8 and angiosarcoma: analysis of 40 cases and review of the literature. Pathology. 2005;37:284-7., 2005	40	none
TOTAL	222	0.06 (13/222)

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Angiosarcoma in HIV-negative patients is not associated with HHV-8* * Work performed at the Universidade de São Paulo (USP) – São Paulo (SP), Brazil.

Abstract:

BACKGROUND:

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSION:

Angiosarcoma in HIV-negative patients is not associated with HHV-8^* * Work performed at the Universidade de São Paulo (USP) – São Paulo (SP), Brazil.