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Anais Brasileiros de Dermatologia

Print version ISSN 0365-0596On-line version ISSN 1806-4841

Abstract

GRANDER, Lara Caroline et al. Multiple cutaneous melanomas associated with gastric and brain metastases. An. Bras. Dermatol. [online]. 2016, vol.91, n.5, suppl.1, pp.98-100. ISSN 0365-0596.  http://dx.doi.org/10.1590/abd1806-4841.20164374.

The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.

Keywords : Cyclin-dependent kinase inhibitor protein; Cyclin-dependent Kinases; Melanoma; Neoplasm metastasis.

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