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Anais Brasileiros de Dermatologia

versión impresa ISSN 0365-0596versión On-line ISSN 1806-4841


OLIVEIRA, Cristiano Claudino; NOBREGA, Vinicius Cardoso  y  MARQUES, Mariângela Esther Alencar. Lymphoepithelioma-like carcinoma of the skin. An. Bras. Dermatol. [online]. 2018, vol.93, n.2, pp.256-258. ISSN 1806-4841.

Primary cutaneous lymphoepithelioma-like carcinoma is a rare disease with low metastatic potential. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. We report the case of a 60-year-old man with an infrapalpebral pearly papule, measuring 0.6 cm in diameter. The lesion was excised with a clinical hypothesis of basal cell carcinoma or squamous cell carcinoma. Histopathological analysis revealed a malignant neoplasm with syncytial arrangement of cells with vesicular nuclei, associated with dense lymphocytic infiltrate. Immunohistochemistry revealed cytokeratin-positive cells (AE1/AE3) and p63 protein, indicating epithelial histogenesis and squamous differentiation. A negative Epstein-Barr virus test result was achieved by immunohistochemistry. Primary lymphoepithelioma-like carcinoma of the skin is a differential diagnosis of lesions with prominent inflammatory infiltrates.

Palabras clave : Immunohistochemistry; Pathology; Skin neoplasms.

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