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Revista Brasileira de Reumatologia

Print version ISSN 0482-5004On-line version ISSN 1809-4570

Abstract

OLIVEIRA, Cristiane Carla de; TEODORO, Walcy Rosolia; VELOSA, Ana Paula Pereira  and  YOSHINARI, Natalino Hajime. Autoimmunity and collagen V. Rev. Bras. Reumatol. [online]. 2006, vol.46, n.3, pp.194-198. ISSN 0482-5004.  http://dx.doi.org/10.1590/S0482-50042006000300006.

The extracellular matrix (ECM) proteins and their components have been widely studied in medical literature, as well its relationship with the tecidual remodeling present in the rheumatic disease. In this paper we show the importance of understanding the role of type V collagen as an important trigger of rheumatic autoimmune diseases. Studies in our laboratory demonstrate that type V collagen sensibilization in rabbits, could result in an animal scleroderma model. In this way we suggested that researches in this field can be worthy in development of new therapeutic procedures.

Keywords : Type V collagen; autoimmunity; scleroderma.

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