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Revista Brasileira de Reumatologia

versão impressa ISSN 0482-5004versão On-line ISSN 1809-4570

Resumo

ROSA, Dario Júnior de Freitas et al. Macrophage activation syndrome following the use of Leflunomide in a patient with adult-onset Still disease: case report. Rev. Bras. Reumatol. [online]. 2007, vol.47, n.3, pp.219-222. ISSN 1809-4570.  http://dx.doi.org/10.1590/S0482-50042007000300013.

A 32-year-old white female, with adult-onset Still disease, was admitted following a 15-day course of leflunomide, with persistent fever and a generalized tonic-clonic seizure. She quickly developed liver and spleen enlargement, impairment of liver function, thrombocytopenia, elevation of lactate-dehydrogenase, trylicerides and ferritin, and renal failure, being diagnosed with the macrophage activation syndrome, a rare complication of rheumatic diseases due to activation and uncontrolled proliferation of T lymphocytes and excessive macrophage activation. The syndrome may lead to disseminated intravascular coagulation, renal impairment being a rare event. Pulse therapy with methylprednisolone and cyclosporine are the therapeutic options.

Palavras-chave : macrophage activation syndrome; Still disease; leflunomide.

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