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Revista Brasileira de Reumatologia
On-line version ISSN 1809-4570
PAIXAO, Ariene; PARANA, Raimundo and SANTIAGO, Mittermayer. Frequency of hepatic abnormalities in patients with scleroderma. Rev. Bras. Reumatol. [online]. 2007, vol.47, n.5, pp. 330-333. ISSN 1809-4570. http://dx.doi.org/10.1590/S0482-50042007000500007.
INTRODUCTION: to determine the frequency of hepatic disease in patients with scleroderma and, secondarily, to investigate the frequency of hepatitis B and C virus infection and determine the frequency of autoantibodies in this disease. MATERIAL AND METHODS: patients with scleroderma followed at Hospital Santa Izabel were included in the study and patients with acne vulgaris served as a comparison group. RESULTS: considering the 65 scleroderma patients, 35% had elevated gamma-glutamyltranspeptidase (gamma-GT), 30% had elevated alkaline phosphatase and 17.1% had alanine aminotransferase (ALT) higher than the reference range. Raised ALT levels were more common in the scleroderma patients than in the control group. Nineteen percent (19%) of the patients tested positive for anti-smooth muscle antibodies and only one patient had anti-mitocondria antibodies. There was no statistical difference between the two groups regarding antibody testing. Anti-HCV antibodies were observed in one patient and HBsAg was detected in another scleroderma patient. There was no patient with clinically significant hepatic disease. CONCLUSIONS: the present study showed that clinical hepatic disease did not occur in our scleroderma patients, despite the relatively increased frequency of liver enzymes abnormalities.
Keywords : scleroderma; systemic sclerosis; liver disease.