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Revista Brasileira de Reumatologia
versão impressa ISSN 0482-5004
SOUZA, Alexandre Wagner Silva de et al. Antinucleosome antibodies and primary antiphospholipid syndrome: an observational study. Rev. Bras. Reumatol. [online]. 2012, vol.52, n.3, pp. 361-365. ISSN 0482-5004. http://dx.doi.org/10.1590/S0482-50042012000300006.
OBJECTIVE: To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up. MATERIALS AND METHODS: Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoimmune diseases and for the presence of antiphospholipid antibodies, antinuclear antibodies and anti-NCS/chromatin antibodies. RESULTS: After a mean follow-up period of 45.7 months, anti-NCS/chromatin antibodies were detected in only one patient (2.8%), who developed features of SLE including polyarthritis, lymphopenia, optic neuritis, multiple sclerosis-like lesions, and an autoantibody profile suggestive of SLE. CONCLUSION: The frequency of anti-NCS/chromatin antibodies in primary APS patients is very low, and they may be associated with the development of SLE manifestations.
Palavras-chave : antiphospholipid syndrome; systemic lupus erythematosus; anticardiolipin antibodies; lupus coagulation inhibitor nucleosomes.