Wallace et al., 19962929 Wallace MS, Dyck JB, Rossi SS, Yaksh TL. Computer-controlled lidocaine
infusion for the evaluation of neuropathic painafter peripheral nerve injury. Pain.
1996;66:69-77.
|
11 (11/11) |
Crossover |
1 |
**** |
**** |
Yes |
Baranowski et al., 19993939 Baranowski AP, De Courcey J, Bonello E. A trial of intravenous lidocaine
on the pain and allodynia of postherpetic neuralgia. J Pain Symptom Manage.
1999;17:429-33.
|
24 (24/24) |
Crossover |
2 |
1 and 5 mg/kg |
2 h |
No |
Attal et al., 20003333 Attal N, Gaudé V, Brasseur L, Dupuy M, Guirimand F, Parker F, et al.
Intravenous lidocaine in central pain: a double-blind, placebo-controlled,
psychophysical study. Neurology.2000;54:564-74.
|
16(16/16) |
Crossover |
1 |
5 mg/kg |
30 min |
Yes |
Finnerup et al., 20054343 Finnerup NB, Biering-Sørensen F, Johannesen IL, Terkelsen AJ, Juhl GI,
Kristensen AD, et al. Intravenous lidocaine relieves spinal cord injury pain: a
randomized controlled trial. Anesthesiology. 2005;102:1023-30.
|
24 (13/11) |
Crossover |
1 |
5 mg/kg |
30 min |
Yes |
Lemming et al., 20051818 Lemming D, Sörensen J, Graven-Nielsen T, Arendt-Nielsen L, Gerdle B. The
responses to pharmacological challenges and experimental pain in patients with
chronic whiplash-associated pain. Clin J Pain. 2005;21:412-21.
|
33 (missing data) |
Crossover |
1 |
5 mg/kg |
30 min |
Yes |
Tremont-Lukats et al., 20062828 Tremont-Lukats IW, Hutson PR, Backonja MM. A randomized, double-masked,
placebo-controlled pilot trial of extended IV lidocaine infusion for relief of
ongoing neuropathic pain. Clin J Pain. 2006;22:266-71.
|
32 (7/9/8/8) |
Parallel |
1 |
1, 3 e 5 mg/kg |
6 h |
Yes (higher dose) |
Attal et al., 20042121 Attal N, Rouaud J, Brasseur L, Chauvin M, Bouhassira D. Systemic
lidocaine in pain due to peripheral nerve injury and predictors of response.
Neurology. 2004;62:218-25.
|
22 (22/22) |
Crossover |
1 |
5 mg/kg |
30 min |
Yes |
Wallace et al., 20003232 Wallace MS, Ridgeway BM, Leung AY, Gerayli A, Yaksh TL.
Concentration-effect relationship of intravenous lidocaine on the allodynia of
complex regional pain syndrome types I and II. Anesthesiology.
2000;92:75-83.
|
16 (16/16) |
Crossover |
1 |
|
|
Yes |
Gottrup et al., 20062525 Gottrup H, Bach FW, Juhl G, Jensen TS. Differential effect of ketamine
and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury
pain. Anesthesiology. 2006;104:527-36.
|
20 (10/10) |
Crossover |
1 |
5 mg/kg |
30 min |
No |
Vlainich et al;, 20101717 Vlainich R, Issy AM, Gerola LR, Sakata RK. Effect of intravenous
lidocaine on manifestations of fibromyalgia. Pain Pract.
2010;10:301-5.
|
30 (15/15) |
Parallel |
4 |
3 mg/kg |
60 min |
No |
Schafranski et al., 20091515 Schafranski MD, Malucelli T, Machado F, Takeshi H, Kaiber F, Schmidt C,
et al. Intravenous lidocaine for fibromyalgia syndrome: an open trial. Clin
Rheumatol. 2009;28:853-5.,
|
23 |
Open |
5 |
2-5 mg/kg |
2 h |
Yes |
Kastrup et al., 19872323 Kastrup J, Petersen P, Dejgård A, Angelo HR, Hilsted J. Intravenous
lidocaine infusion: a new treatment of chronic painful diabetic neuropathy?
1987.
|
15 (8/7) |
Crossover |
1 |
5 mg/kg |
30 min |
Yes |
Kvarnström et. al., 2003/200466 Kvarnström A, Karlsten R, Quiding H, Gordh T. The analgesic effect of
intravenous ketamine and lidocaine on pain after spinal cord injury. Acta
Anaesthesiol Scand. 2004;48:498-506.,2727 Kvarnström A, Karlsten R, Quiding H, Emanuelsson BM, Gordh T. The
effectiveness of intravenous ketamine and lidocaine on peripheral neuropathic pain.
Acta Anaesthesiol Scand. 2003;47:868-77.
|
10 (10/10) |
Crossover |
1 |
2,5 mg/kg |
40 min |
No |
Ferrante et al., 19964040 Ferrante FM, Paggioli J, Cherukuri S, Arthur GR. The analgesic response
to intravenous lidocaine in the treatment of neuropathic pain. Anesth Analg.
1996;82:91-7.,
|
13 |
Open |
1 |
500 mg |
60 min |
Yes |
Gormsen et al., 20092626 Gormsen L, Finnerup NB, Almqvist PM, Jensen TS. The efficacy of the AMPA
receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized,
double-blind, placebo-controlled, three-way crossover study. Anesth
Analg.2009;108:1311-9.
|
15 (15/13) |
Crossover |
1 |
5 mg/kg |
4 h |
No |
Viola et al., 20062424 Viola V, Newnham HH, Simpson RW. Treatment of intractable painful
diabetic neuropathy with intravenous lignocaine. 2006.
|
15 (15/15/15) |
Crossover |
2 |
5 e 7,5 mg/kg |
4 h |
Yes |
Wu et al., 20022222 Wu CL, Tella P, Staats PS, Vaslav R, Kazim DA, Wesselmann U, et al.
Analgesic effects of intravenous lidocaine and morphine on postamputation pain: a
randomized doubleblind, active placebo-controlled, crossover trial. Anesthesiology.
2002;96:841-8.
|
32 (11/11/12) |
Crossover |
1 |
5 mg/kg |
42 min |
No |
Author(s)/year |
Reduction of pain (%) |
No. of patients who reported relief in each group
(cases/controls) |
Duration of effect |
Plasma concentration at which there was relief |
Adverse effects |
Jadad score |
Wallace et al., 19962929 Wallace MS, Dyck JB, Rossi SS, Yaksh TL. Computer-controlled lidocaine
infusion for the evaluation of neuropathic painafter peripheral nerve injury. Pain.
1996;66:69-77.
|
>50 |
|
|
1,5-2,5 μg/mL |
Delirium, nausea |
2 |
Baranowski et al., 19993939 Baranowski AP, De Courcey J, Bonello E. A trial of intravenous lidocaine
on the pain and allodynia of postherpetic neuralgia. J Pain Symptom Manage.
1999;17:429-33.
|
~ 50 (1 mg/kg) and >30 (5 mg/kg) |
|
|
1,7 μg/ml |
Perioral paraesthesia (higher dose) |
2 |
Attal et al., 20003333 Attal N, Gaudé V, Brasseur L, Dupuy M, Guirimand F, Parker F, et al.
Intravenous lidocaine in central pain: a double-blind, placebo-controlled,
psychophysical study. Neurology.2000;54:564-74.
|
~50 |
10/6 |
45 min |
|
|
4 |
Finnerup et al., 20054343 Finnerup NB, Biering-Sørensen F, Johannesen IL, Terkelsen AJ, Juhl GI,
Kristensen AD, et al. Intravenous lidocaine relieves spinal cord injury pain: a
randomized controlled trial. Anesthesiology. 2005;102:1023-30.
|
>30 |
19/4 |
|
1,5-4,1 μg/mL |
Delirium, dizziness, drowsiness, dysarthria, blurred
vision, tremors, dry mouth, headache. |
5 |
Lemming et al., 20051818 Lemming D, Sörensen J, Graven-Nielsen T, Arendt-Nielsen L, Gerdle B. The
responses to pharmacological challenges and experimental pain in patients with
chronic whiplash-associated pain. Clin J Pain. 2005;21:412-21.
|
|
11/2 |
|
|
|
5 |
Tremont-Lukats et al., 20062828 Tremont-Lukats IW, Hutson PR, Backonja MM. A randomized, double-masked,
placebo-controlled pilot trial of extended IV lidocaine infusion for relief of
ongoing neuropathic pain. Clin J Pain. 2006;22:266-71.
|
>30 |
**** |
6 h |
|
Delirium, nausea/vomiting, diplopia, headache,
tinnitus, perioral paresthesia, metallic taste, tightness in
throat. |
5 |
Attal et al., 20042121 Attal N, Rouaud J, Brasseur L, Chauvin M, Bouhassira D. Systemic
lidocaine in pain due to peripheral nerve injury and predictors of response.
Neurology. 2004;62:218-25.
|
>60 |
11/*** |
6 h |
|
Delirium, drowsiness, perioral numbness, truncated
speech, dizziness, dysarthria. |
5 |
Wallace et al., 20003232 Wallace MS, Ridgeway BM, Leung AY, Gerayli A, Yaksh TL.
Concentration-effect relationship of intravenous lidocaine on the allodynia of
complex regional pain syndrome types I and II. Anesthesiology.
2000;92:75-83.
|
≥ 25 |
|
|
3 μg/mL |
Delirium |
2 |
Gottrup et al., 20062525 Gottrup H, Bach FW, Juhl G, Jensen TS. Differential effect of ketamine
and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury
pain. Anesthesiology. 2006;104:527-36.
|
~10 |
4/0 |
|
|
Delirium, nausea, paresthesia, blurred vision,
dizziness, dysarthria, headache, dry mouth. |
4 |
Vlainich et al;, 20101717 Vlainich R, Issy AM, Gerola LR, Sakata RK. Effect of intravenous
lidocaine on manifestations of fibromyalgia. Pain Pract.
2010;10:301-5.
|
>45 |
|
|
|
|
4 |
Schafranski et al., 20091515 Schafranski MD, Malucelli T, Machado F, Takeshi H, Kaiber F, Schmidt C,
et al. Intravenous lidocaine for fibromyalgia syndrome: an open trial. Clin
Rheumatol. 2009;28:853-5.,
|
>15and >10 (after 30 days) |
|
30 days |
|
No adverse effects |
Not applicable |
Kastrup et al., 19872323 Kastrup J, Petersen P, Dejgård A, Angelo HR, Hilsted J. Intravenous
lidocaine infusion: a new treatment of chronic painful diabetic neuropathy?
1987.
|
>40 (1-3 days) and >15 |
9/4 |
3-21 days |
|
|
2 |
Kvarnström et. al., 2003/200466 Kvarnström A, Karlsten R, Quiding H, Gordh T. The analgesic effect of
intravenous ketamine and lidocaine on pain after spinal cord injury. Acta
Anaesthesiol Scand. 2004;48:498-506.,2727 Kvarnström A, Karlsten R, Quiding H, Emanuelsson BM, Gordh T. The
effectiveness of intravenous ketamine and lidocaine on peripheral neuropathic pain.
Acta Anaesthesiol Scand. 2003;47:868-77.
|
~10 (>50 in 1 patient) |
1/0 |
|
|
Drowsiness, perioral paresthesia. |
4 |
Ferrante et al., 19964040 Ferrante FM, Paggioli J, Cherukuri S, Arthur GR. The analgesic response
to intravenous lidocaine in the treatment of neuropathic pain. Anesth Analg.
1996;82:91-7.,
|
100 (100 patients), 62, 55 and 40 (the other) |
13 |
|
0,62 μg/mL |
|
Not applicable |
Gormsen et al., 20092626 Gormsen L, Finnerup NB, Almqvist PM, Jensen TS. The efficacy of the AMPA
receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized,
double-blind, placebo-controlled, three-way crossover study. Anesth
Analg.2009;108:1311-9.
|
~36 |
11/8 |
|
|
Drowsiness, perioral paresthesia, headache, dizziness,
fatigue, discomfort, dry mouth, nausea, muscle spasms. |
5 |
Viola et al., 20062424 Viola V, Newnham HH, Simpson RW. Treatment of intractable painful
diabetic neuropathy with intravenous lignocaine. 2006.
|
|
|
28 days |
|
Delirium (higher dose) |
3 |
Wu et al., 20022222 Wu CL, Tella P, Staats PS, Vaslav R, Kazim DA, Wesselmann U, et al.
Analgesic effects of intravenous lidocaine and morphine on postamputation pain: a
randomized doubleblind, active placebo-controlled, crossover trial. Anesthesiology.
2002;96:841-8.
|
~30 |
|
|
|
|
4 |