Anti-Müllerian hormone levels as a predictor of ovarian reserve in systemic lupus erythematosus patients: a review

Gasparin, Andrese Aline; Chakr, Rafael Mendonça da Silva; Brenol, Claiton Viegas; Palominos, Penélope Ester; Xavier, Ricardo Machado; Souza, Lucian; Brenol, João Carlos Tavares; Monticielo, Odirlei André

doi:10.1016/j.rbr.2014.05.008

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Review articles • Rev. Bras. Reumatol. 55 (4) • Jul-Aug 2015 • https://doi.org/10.1016/j.rbr.2014.05.008 copy

Anti-Müllerian hormone levels as a predictor of ovarian reserve in systemic lupus erythematosus patients: a review

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

The anti-Müllerian hormone (AMH) is secreted from granulosa cells of growing ovarian follicles and appears to be the best endocrine marker capable of estimating ovarian reserve. Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women of reproductive age and may negatively affect their fertility due to disease activity and the treatments used. Recently, several studies assessed AMH levels to understand the real impact of SLE and its treatment on fertility.

Keywords:
Anti-Müllerian hormone; Ovarian reserve; Systemic lupus erythematosus

Study	Design	Follow-up	Main results
Lawrenz et al. ²⁸28 Lawrenz JC, Henes M, Henes E, Neunhoeffer M, Schmalzing T, Fehm, et al. Impact of systemic lupus erythematosus on ovarian reserve in premenopausal women: Evaluation by using anti-Müllerian hormone. Lupus. 2011;20:1193–7.	Case–control (33 patients in each group)	February 2009 to May 2010, Germany	SLE patients have significantly lower AMH levels than healthy controls.
Mok et al. ²⁹29 Mok CC, Chan PT, To CH. Anti-Müllerian hormone and ovarian reserve in systemic lupus erythematosus. Arthritis Rheum. 2013;65:206–10.	Cohort study, 216 SLE patients	June to October, 2009, China	The mean AMH level was significantly lower in patients who had been previously exposed to cyclophosphamide.
Morel et al. ³⁰30 Morel N, Bachelot A, Ghillani-Dalbin P, Amoura Z, Galicier L. Study of anti-Müllerian hormone and the relationship with subsequent probability of pregnancy in 112 systemic lupus erythematosus patients exposed or not to cyclophosphamide. Lupus. 2013;22:16. The 10th International Congress on SLE, April 18-21 2013, Buenos Aires, Argentina.	Case–control (56 patients in each group)	2012, France	Low AMH levels in SLE patients, with significant decrease associated with age and prior use of cyclophosphamide.
Malheiro et al. ³¹31 Malheiro OB, Rezende CP, Ferreira GA, Reis FM. Federal University of Minas Gerais, Brazil. Ovarian reserve markers in reproductive age women with systemic lupus erythematosus. Lupus. 2013;22:162. The 10th International Congress on SLE, April 18-21 2013, Buenos Aires, Argentina.	Case–control (27 patients in each group)	Brazil	The mean values of ovarian reserve were similar in both groups. SLE patients showed wider distribution of AMH values.

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[1] *Corresponding author. E-mail: andresegasparin@gmail.com (A.A. Gasparin).