The importance of lactic acid in migraines and fibromyalgia

Ribeiro, Guido Assis Cachuba de Sá; Scola, Rosana Hermínia; Piovesan, Elcio Juliato; Wollmann Junior, Darley Rugeri; Paiva, Eduardo dos Santos; Cunha, Claudio Leinig Pereira da; Werneck, Lineu Cesar

doi:10.1016/j.rbr.2015.02.002

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Original articles • Rev. Bras. Reumatol. 55 (6) • Nov-Dec 2015 • https://doi.org/10.1016/j.rbr.2015.02.002 copy

The importance of lactic acid in migraines and fibromyalgia^☆ ☆ The study was conducted at the Neurology, Cardiology and Rheumatology Services, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Background:

Lactic acid is a byproduct of both muscle metabolism and the central nervous system. Changes in metabolism are related to various physiological and pathological conditions. The aim of this study was to determine the relationship between migraine and fibromyalgia with the levels of lactic acid in the blood.

Methods:

We study 93 patients divided into five groups: (1) patients with fibromyalgia (n = 20); (2) episodic migraine (n = 20); (3) chronic migraine (n = 20); (4) fibromyalgia and episodic migraine (n = 13); and (5) fibromyalgia and chronic migraine (n = 20), and 20 healthy subjects (control group). Blood levels of lactic acid were measured at four different time points: at rest, during aerobic exercise, during anaerobic physical activity and while resting after anaerobic exercise.

Results:

Lactic acid increased in all groups during anaerobic physical activity without predominance for either group. During aerobic physical activity, all groups increased lactic acid levels, but the increase was more expressive in the chronic migraine group and the chronic migraine with fibromyalgia group without statistical significance.

Conclusions:

We did not found abnormalities involving the metabolism of lactic acid in episodic and chronic migraine with or without fibromyalgia.

Keywords
Chronic migraine; Episodic migraine; Lactic acid; Fibromyalgia

Group	Number of cases^a a All cases were females.	Age (years-old) Mean ± SD Min–max	Weight (kg) Mean ± SD Min–max	Height (m) Mean ± SD Min–max	Body index mass Mean ± SD Min–max
Controls	20	42.60 ± 9.36 (22–56)	66.75 ± 9.15 (53–84)	1.64 ± 0.76 (1.53–1.80)	24.95 ± 3.90 (18.59–34.17)
Fibromyalgia	20	47.35 ± 6.33 (32–57)	65.75 ± 12.38 (46–90)	1.60 ± 0.54 (1.49–1.70)	25.65 ± 4.98 (18.81–34.07)
Episodic migraine	20	37.75 ± 10.54 (21–59)	65.95 ± 12.68 (46–90)	1.62 ± 0.67 (1.50–1.76)	25.24 ± 5.21 (17.85–35.15)
Chronic migraine	20	39.15 ± 12.13 (26–67)	65.15 ± 11.88 (45–100)	1.60 ± 0.78 (1.47–1.79)	25.71 ± 5.34 (20.00–42.16)
Episodic migraine plus fibromyalgia	13	46.92 ± 8.64 (30–62)	71.08 ± 4.70 (65–80)	1.61 ± 0.55 (1.53–1.72)	27.33 ± 2.35 (23.87–30.86)
Chronic migraine plus Fibromyalgia	20	44.30 ± 6.45 (31–57)	66.45 ± 12.39 (44–92)	1.61 ± 0.73 (1.50–1.76)	25.56 ± 4.16 (19.04–31.59)

Group	Number of cases	Rest (mmol/L) Mean ± SD	Aerobic (mmol/L) Mean ± SD	Anaerobic (mmol/L) Mean ± SD	Rest post exercise (mmol/L) Mean ± SD
Controls	20	2.39 ± 0.88	2.82 ± 2.41	3.64 ± 1.31	3.34 ± 1.24
Fibromyalgia	20	2.33 ± 1.08	2.38 ± 1.71	4.32 ± 1.96	3.37 ± 1.56
Episodic migraine	20	2.93 ± 1.38	3.22 ± 2.70	3.22 + 0.96	3.25 ± 1.39
Chronic migraine	20	2.79 ± 1.25	3.40 ± 1.91 p = 0.048^a a Statistical significance in relation to the control group before Bonferroni Correction (Mann–Whitney U test).	4.21 ± 1.56	3.44 ± 1.19
Episodic migraine plus fibromyalgia	13	2.40 ± 0.83	2.05 ± 0.81	4.15 ± 3.40	3.05 ± 1.60
Chronic migraine plus fibromyalgia	20	3.23 ± 1.95	3.87 ± 2.53 p = 0.042^a a Statistical significance in relation to the control group before Bonferroni Correction (Mann–Whitney U test).	3.43 ± 1.48	3.16 ± 1.27

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[1] *Corresponding author. E-mail: lineu.werneck@hc.ufpr.br (L.C. Werneck).

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The importance of lactic acid in migraines and fibromyalgia☆ ☆ The study was conducted at the Neurology, Cardiology and Rheumatology Services, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.

Abstract

Background:

Methods:

Results:

Conclusions:

The importance of lactic acid in migraines and fibromyalgia^☆ ☆ The study was conducted at the Neurology, Cardiology and Rheumatology Services, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.