Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients

Grecco, Marcelle; Santos, Viviane Cardoso dos; Pereira, Kaline Medeiros Costa; Andrade, Luís Eduardo Coelho; Silva, Neusa Pereira da

doi:10.1016/j.rbre.2016.07.013

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Revista Brasileira de Reumatologia

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Original articles • Rev. Bras. Reumatol. 56 (6) • Nov-Dec 2016 • https://doi.org/10.1016/j.rbre.2016.07.013 copy

Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease.

Keywords:
Systemic lupus erythematosus; Fc gamma receptor IIIa; Single nucleotide polymorphism; Gene polymorphism; Immunogenetics

	SLE		Controls
Ethnicity	n	%	n	%	p ^a a Chi-square test.
Black	12	3.9	16	5.4	0.113
White	111	36.4	130	43.3
Mixed	182	59.7	154	51.3
Gender	Female	Male	Female	Male	p ^a a Chi-square test.
	291	14	178	122	<0.001

	SLE			Controls
Genotype	n	%		n	%	p ^a a Chi-square test.	p ^b b Bonferroni correction for multiple comparisons method.
VV	35	11.5		54	18.0	0.002	0.023
FF	23	7.5		39	13.0		0.027
VF	247	81.0		207	69.0		<0.001
Allele	n		%	n		%	p ^c c Chi-square test.
V	317		52.0	315		52.5	0.853
F	293		48.0	285		47.5

Manifestation (n)		VV		FF		VF		p ^a a Chi-square test.
Manifestation (n)		n	%	n	%	n	%
Skin (178)	⊕	16	100.0	6	100.0	147	94.0	0.511
Skin (178)	∅	0	0.0	0	0.0	9	6.0
Oral ulcers (145)	⊕	1	6.7	0	0.0	28	22.6	0.158
Oral ulcers (145)	∅	14	93.3	6	100.0	96	77.4
Arthritis (178)	⊕	16	100.0	6	100.0	138	88.5	0.244
Arthritis (178)	∅	0	0.0	0	0.0	18	11.5
Hematologic (178)	⊕	10	62.5	5	83.3	116	74.3	0.509
Hematologic (178)	∅	6	37.5	1	16.7	40	25.7
Renal (178)	⊕	10	62.5	2	33.3	88	56.4	0.463
Renal (178)	∅	6	37.5	4	66.7	68	43.6
Serositis (178)	⊕	4	25.0	1	16.7	38	24.3	0.909
Serositis (178)	∅	12	75.0	5	83.3	118	75.7
CNS (177)	⊕	9	53.3	1	17.7	30	19.4	0.003
CNS (177)	∅	7	43.8	5	83.3	125	80.6

Autoantibody	Genotype						p ^a a Chi-square test.
	VV (n = 35)		FF ( n = 23)		VF ( n = 247)
	+	%	+	%	+	%
Anti-dsDNA	12	34.3	8	34.8	72	29.1	0.832
Anti-Sm	8	22.9	6	26.1	37	15.0	0.231
Anti-RNP	15	42.9	8	34.8	73	29.6	0.267
Anti-SS-A/Ro	8	22.9	10	43.5	74	30.0	0.243
Anti-SS-B/La	0	0	3	13.0	25	10.1	0.122

Ethnicity	Patients (n)	Increased susceptibility	Genotypic association	Phenotype association		Ref	Year publication
Ethnicity	Patients (n)	Increased susceptibility	Genotypic association	Clinical trait	p ^a a Chi-square test.	Ref	Year publication
Korean	148	No	158 F/F	Nephritis	<0.007	²⁰20 Salmon JE, Ng S, Yoo DH, Kim TH, Kim SY, Song GG. Altered distribution of Fcgamma receptor IIIA alleles in a cohort of Korean patients with lupus nephritis. Arthritis Rheum. 1999;42:818-9.	1999
African-American	77	No	ND	No	ND	¹²12 Oh M, Petri MA, Kim NA, Sullivan KE. Frequency of the FcγRIIIA-158F allele in African American patients with systemic lupus erythematosus. J Rheumatol. 1999;26:1486-9.	1999
Japanese	193	Yes	158 F/F	Nephritis	0.03	¹⁵15 Kyogoku C, Dijstelbloem HM, Tsuchiya N, Hatta Y, Kato H, Yamaguchi A, et al. Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum. 2002;46:1242-54.	2002
Spanish	276	No	ND	No	ND	¹⁴14 González-Escribano MF, Aguilar F, Sánchez-Román J, Núñez-Roldán A. FcgammaRIIA, FcgammaRIIIA and FcgammaRIIIB polymorphisms in Spanish patients with systemic lupus erythematosus. Eur J Immunogenet. 2002;29:301-6.	2002
Korean	145	No	ND	No	ND	²¹21 Lee EB, Lee YJ, Baek HJ, Kang SW, Chung ES, Shin CH, et al. Fcgamma receptor IIIA polymorphism in Korean patients with systemic lupus erythematosus. Rheumatol Int. 2002;21:222-6.	2002
German	140	No	ND	No	ND	¹21 Lee EB, Lee YJ, Baek HJ, Kang SW, Chung ES, Shin CH, et al. Fcgamma receptor IIIA polymorphism in Korean patients with systemic lupus erythematosus. Rheumatol Int. 2002;21:222-6.	2002
Thai	87	Trend	158 F/F	Malar rash	0.03	¹⁹19 Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, et al. Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens. 2003;61:374-83.	2003
		Trend		Discoid rash	0.04
Mexican	94	No	ND	No	ND	¹¹11 Brambila-Tapia AJ, Gámez-Nava JI, González-López L, Sandoval-Ramírez L, Medína-Díaz J, Maldonado M, et al. FCGR3A V (176) polymorphism for systemic lupus erythematosus susceptibility in Mexican population. Rheumatol Int. 2011;31:1065-8.	2011

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[1] *Corresponding author. E-mail: npsilva@unifesp.br (N.P. Silva).