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Acta Ortopédica Brasileira

Print version ISSN 1413-7852On-line version ISSN 1809-4406


CAMPOS, Wilson Galego. Effect of the ossein-hydroxyapatite complex on fracture consolidation under protein malnutrition: experimental study using rats. Acta ortop. bras. [online]. 2001, vol.9, n.2, pp.21-25. ISSN 1809-4406.

Assessement of the effect of ossein-hidroxiapatite compound in the fracture healing under protein malnutrition: experimental essay in rats. An experimental essay was carried out with 40 Wistar male rats to assess the effect of the ossein-hidroxiapatite compound (OHC) in the fracture healing in animal under protein diet and no protein diet, which were divided into four groups, at random, which received or did not receive the compound. Each group with 10 animals, was divided into: group I, protein diet, without OHC; group II, protein diet, with OHC; group III, no protein diet, without OHC; group IV, no protein diet, with OHC. The fractures were made similarly as to the trace and site in all groups in the 15th day, when groups II and IV started receiving a daily dose of 20mg of the OHC, orally. Blood samples were drawn from all groups on the 1st , 15th and 43rd days. The animals underwent euthanasia on the 43rd day. Weight control as well as calcium, phosphorus, alkaline phosphatase total proteins, albumin, and osteocalcine were determined. The fractured limb was desarticulated in the hip joint on the 43rd day, and the bone callus was submitted to histological, histomorphometric, radiographic, planimetric and densitometric examination. It was concluded, after statistical analysis, that the OHC did not interfere significantly, in general assessment in bone callus formation in malnutrition and nourished animals. However it showed significant interference in some results such as albumin and alkaline phosphatase blood samples, in the planimetry and weight of the animals.

Keywords : Experimental Study; Osseous Consolidation; Ossein-Hidroxiapatite Compound.

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