A comparative study was performed of the reaction of triceps sural and abdominal retus muscle of Wistar mice to implantation of polysulfone (PSU) and ultra high molecular weight poliethilene (UHMWPE) as particles and rods, for a period up to 52 weeks. At the end, PSU was considered as having the same biocompatibility as UHMWPE, according to the used method.