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Acta Ortopédica Brasileira

versão impressa ISSN 1413-7852versão On-line ISSN 1809-4406

Resumo

CROCI, Alberto Tesconi et al. Effect of plasma concentrate on bone defects induced in mice fêmurs via stimulation of bone formation: an experimental study. Acta ortop. bras. [online]. 2003, vol.11, n.4, pp.230-239. ISSN 1413-7852.  http://dx.doi.org/10.1590/S1413-78522003000400006.

In this trial the authors investigated the effect of plasma concentrate on bone callus formation in mice. Ten mice of the Gioto isogenic mouse strain were used; samples of peripheral blood of each mouse were collected and centrifuged, giving a plasma concentrate that was used to investigate bone defects at the distal region of the femur; the right and left sides were used alternately, and one side showed a single bone defect; the plasma concentrate was analyzed both qualitatively and quantitatively. It was noticed that the plasma concentrate did not lead to any stimulation of bone callus formation and no inflammatory effect increase has occurred; also, its use showed only a tendency to increase bone matrix formation.

Palavras-chave : Mice; Inbred strains; Plasma; Bony callus, Bone matrix.

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