A experimental study with 40 rats of the Lewis type was done focusing the influence of sodic risedronate on fractures consolidation in the animals. They were submitted to a protein nutrition diet to a non-protein one, divided randomly in four groups, having 10 animals in each group. Like this: group 1, with a protein nutrition diet, without risedronate (control group); group II, protein nutrition diet t with risedronate , group III, non-protein diet, without risedronate; group IV, non-protein diet with risedronate. The rats were submitted to similar fractures, on the 15º day and to the euthanasia on the 43º of the experiment. The variability analyzed included the ponderous evaluation, radiographic evaluation, the bone densitometry, histomorphometric bone callus evaluation, blood dosage of calcium, phosphorus, alkaline phosphatase, total proteins, albumin and osteocalcin. It was found out the risedronate had positive influence on the fractures consolidation process in nourished rats and malnourished rats and the mineral bone density increased. The risedronate caused the formation of the best nutrition and morphology of the ripen bone tissue.
Protein malnutrition; Risedronate; Fracture healing; Rats
