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Acta Ortopédica Brasileira

versão impressa ISSN 1413-7852versão On-line ISSN 1809-4406

Resumo

BRAGA-SILVA, Jefferson et al. Bone marrow and platelet-rich plasma stem cells effects on nervous regeneration and functional recovery in an acute defect model of rats' peripheral nerve. Acta ortop. bras. [online]. 2006, vol.14, n.5, pp.273-275. ISSN 1809-4406.  https://doi.org/10.1590/S1413-78522006000500009.

OBJECTIVES: The effects of the use of bone marrow stem cells (MSC) and platelet-rich plasma (PRP) on peripheral nerves regeneration were assessed by using an established model of sciatic nerve regeneration in rats. METHODS: A 10-mm nervous defect was reconstructed by using a silicone tube filled with MSC, PRP or both. The control group received only the silicone tube. A fifth group was also set, in which the interval was reconstructed by using a dried segment of the nerve. Motor function was tested six weeks after surgery, by means of a gait test. After motor test, the rats were anesthetized, the sciatic nerve and the tube were dried, and the transmission electronic microscopy was performed. RESULTS: The quantitative analysis shows an improved functional recovery in MSC group compared to the other groups. Nervous regeneration was reported for MSC group by means of transmission electronic microscopy with an almost full recovery of the neural anatomy. CONCLUSION: Our results suggest that the use of MSC combined with tubing technique yields a satisfactory recovery of motor function and nervous regeneration.

Palavras-chave : Stem Cells; Peripheral Nerves; Models, Animal.

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