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Acta Ortopédica Brasileira
On-line version ISSN 1809-4406
LEMOS, Sandro Pinheiro de Souza et al. Glycerol-preserved allogenous nerve: an experimental study with rats. Acta ortop. bras. [online]. 2008, vol.16, n.3, pp. 133-137. ISSN 1809-4406. http://dx.doi.org/10.1590/S1413-78522008000300001.
The use of glycerol-preserved nerve allograft is an alternative to autografting in cases of peripheral nerve injury with loss of substance, which decreases surgical morbidity and provides sufficient material for neural repair. The objective of this study was to compare the degree of nervous repair, through interposition of autogenous graft (Group A), of glycerol-preserved vein tube (Group B), and interposition of glycerol-preserved allogenic nerve (Group C) in 5-mm defects of Wistar rats' fibular nerve, using histological and functional analyses. In group A (autograft) a perineural tissue reaction and myelinated axonal fibers escape out of the epineurium boundaries were greater when compared to those observed in Group B (autogenous vein + glycerol) and Group C (nerve allograft). The functional evaluation was made by analysis of the patterns of rats' posterior footprints (Walking Track Analysis) in preoperative, early postoperative period, week 3 and week 6. Regarding functional recovery, in none of the evaluated periods was there a statistically significant difference between the three groups.
Keywords : Transplant; Nervous regeneration; Glycerol; Fibular nerve; Wistar rats; Surgery [methods].