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Brazilian Journal of Infectious Diseases
On-line version ISSN 1678-4391
GONCALVES, Maria Alice Guimarães and DONADI, Eduardo Antonio. Immune cellular response to HPV: current concepts. Braz J Infect Dis [online]. 2004, vol.8, n.1, pp. 1-9. ISSN 1678-4391. http://dx.doi.org/10.1590/S1413-86702004000100001.
Although cellular immunity is essential for the elimination of human papillomavirus (HPV), the mechanisms involved are still poorly understood. We summarize the main mechanisms involved in cellular immune response to infections caused by HPV. Immunotherapies for HPV-related cancers require the disruption of T-cell response control mechanisms, associated with the stimulation of the Th1 cytokine response.
Keywords : Human papillomavirus (HPV); cervical intraepithelial neoplasia (CIN); uterine cervical cancer; cellular immune response; cytokines.