Brazilian Journal of Infectious Diseases
On-line version ISSN 1678-4391
MENDES, Caio et al. Klebsiella pneumoniae with multiple antimicrobial resistance. Braz J Infect Dis [online]. 2004, vol.8, n.1, pp. 109-111. ISSN 1678-4391. http://dx.doi.org/10.1590/S1413-86702004000100008.
A Klebsiella pneumoniae strain was isolated from the urine of a patient at one of the centers participating in the 2001 edition of the MYSTIC program in Brazil. The initial phenotypic findings of the isolated K. pneumoniae presented an unusual MIC of 8 mg/mL to meropenem, 2 mg/mL to imipenem, elevated MICs to broad spectrum cephalosporins (ceftazidime/cefotaxime/cefepime MIC > 256 mg/mL), aminoglycosides (gentamycin > 256 mg/mL and tobramycin = 48 mg/mL), piperacillin/tazobactam (MIC > 256 mg/mL) and susceptibility to ciprofloxacin (MIC = 0.25 mg/mL). The strain also tested positive for ESBL production with double-disk and E-test methodologies. More detailed investigation revealed that the strain produced a SHV-4 type enzyme and also lacked a 36 kDa outer membrane porin.
Keywords : Klebsiella pneumoniae; drug effects; drug resistance; carbapenems.