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Brazilian Journal of Infectious Diseases
Print version ISSN 1413-8670On-line version ISSN 1678-4391
LEITE, Andréa Gurgel Batista et al. Cerebral infarction related to cryptococcal meningitis in an HIV-infected patient: case report and literature review. Braz J Infect Dis [online]. 2004, vol.8, n.2, pp.175-179. ISSN 1413-8670. http://dx.doi.org/10.1590/S1413-86702004000200008.
Neurological dysfunction as the first manifestation of AIDS has been found in 10 to 20% of symptomatic human immunodeficiency virus infections. However, stroke has rarely been reported in AIDS patients. The most common causes of cerebral infarction in AIDS are central nervous system infections: toxoplasmosis, cryptococcal meningitis and tuberculosis. Potential vascular mechanisms for cerebral infarction and transient neurological deficits among AIDS patients include deposition of antigen-antibody complexes with vasculitis and infarction, and a direct toxic effect of a viral antigen or infectious agent on vascular endothelium. The role of cryptococcal meningitis in vasculopathy is still not clear. We report a case of cerebral infarction in an HIV-infected patient, with cryptococcal meningitis as the first manifestation of AIDS.
Keywords : AIDS; cerebral infarction; stroke; cryptococcal meningitis.