Brazilian Journal of Infectious Diseases
versão impressa ISSN 1413-8670
versão On-line ISSN 1678-4391
ROSA, Daniela Dornelles; PASQUALOTTO, Alessandro C.; QUADROS, Maurício de e PREZZI, Sérgio Henrique. Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis: case report and literature review. Braz J Infect Dis [online]. 2004, vol.8, n.4, pp.328-330. ISSN 1413-8670. http://dx.doi.org/10.1590/S1413-86702004000400010.
The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.
Palavras-chave : Meningococcal disease; Neisseria meningitidis; complement deficiency.