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Brazilian Journal of Infectious Diseases

Print version ISSN 1413-8670On-line version ISSN 1678-4391

Abstract

BRANDAO, Paulo Eduardo et al. Short-interfering RNAs as antivirals against rabies. Braz J Infect Dis [online]. 2007, vol.11, n.2, pp.224-225. ISSN 1413-8670.  https://doi.org/10.1590/S1413-86702007000200011.

This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.

Keywords : siRNA; rabies; antiviral.

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