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Brazilian Journal of Infectious Diseases

Print version ISSN 1413-8670

Abstract

FAHL, Willian Oliveira et al. Desmodus rotundus and Artibeus spp. bats might present distinct rabies virus lineages. Braz J Infect Dis [online]. 2012, vol.16, n.6, pp.545-551. ISSN 1413-8670.  https://doi.org/10.1016/j.bjid.2012.07.002.

In Brazil, bats have been assigned an increasing importance in public health as they are important rabies reservoirs. Phylogenetic studies have shown that rabies virus (RABV) strains from frugivorous bats Artibeus spp. are closely associated to those from the vampire bat Desmodus rotundus, but little is known about the molecular diversity of RABV in Artibeus spp. The N and G genes of RABV isolated from Artibeus spp. and cattle infected by D. rotundus were sequenced, and phylogenetic trees were constructed. The N gene nucleotides tree showed three clusters: one for D. rotundus and two for Artibeus spp. Regarding putative N amino acid-trees, two clusters were formed, one for D. rotundus and another for Artibeus spp. RABV G gene phylogeny supported the distinction between D. rotundus and Artibeus spp. strains. These results show the intricate host relationship of RABV's evolutionary history, and are invaluable for the determination of RABV infection sources.

Keywords : Rabies Bat Artibeus spp.; Desmodus rotundus; Phylogeny; Molecular epidemiology.

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